2015 Study shows long-term hormone treatment (HRT) for trans people is safe


Hormones post

Years ago when many of use began HRT we didn’t know what the long term effects might have been. Many of us were faced with an ignorant and biased medical profession, who also didn’t know.

Many of those doctors knew how difficult it was to find anyone who would prescribe HRT. These predatory doctors would charge outrageous office fees leaving many of us with no option but to self-medicate.

Not to mention the ‘gatekeeper’ therapist who would lead on clients for months, even years, with a vague notion that someday they might fit neatly into their concept of man or woman to deserve the ‘HRT letter’ to present to a prescribing doctor, if one could be found.
All the while those therapists would rake in the dough from hopeful cash-strapped transgender victims.

I hope that you haven’t experienced any combination of these unscrupulous providers during your trip down our road less taken, but if you have…..

All that is changing now. We are educating the medical profession and ending our victimization by greedy immoral therapists.

A groundbreaking study titled “Hormone therapy in transgender adults is safe with provider supervision; A review of hormone therapy sequelae for transgender individuals” will help.

From the study:

Credit: A study by the Weinand JD, Safer JD, Hormone therapy in transgender adults is safe with
provider supervision; A review of hormone therapy sequelae for transgender individuals. The Accepted manuscript will appear in the Journal of Clinical & Translational Endocrinology (2015).

•We review the relative safety of hormone treatment for transgender individuals.
•Estrogen treatment for transgender women may increase risk of thrombosis.
•Androgen treatment for transgender men may increase risk of polycythemia.
•Hormone therapy has not been shown to increase transgender individuals’ cancer risk.

Current literature suggests HT is safe when followed carefully for certain risks. The greatest health concern for HT in transgender women is venous thromboembolism. HT among transgender men appears to cause polycythemia. Both groups experienced elevated fasting glucose. There is no increase in cancer prevalence or mortality due to transgender HT.

Although current data support the safety of transgender HT with physician supervision, larger, long-term studies are needed in transgender medicine.


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Kelli, Busey is managing editor at Planet Transgender


  1. Thank you for the information. I was wondering if I should quit the meds of not. I have had surgery and the only natural hormones I receive is from the pituitary gland. I don’t have any sex glands that I know of. I have been on hormones for 16 years and I’m in my mid 60’s.

  2. Hi there! Thank you again so much for writing about our paper! As an openly transgender person myself (FTM transguy) and current 2nd-year medical student at Boston University, I feel really strongly that this trend of inadequate and uninformed transgender health care must be reversed! The UCSF Center for Excellence of Transgender Health notes that over 50% of trans*/GNC people must educate their healthcare providers about their own care. This can no longer be the status-quo! I also agree with this article in that it’s inappropriate to continue to sponsor a gatekeeper model.

    If you have any questions about our article please don’t hesitate to get in touch with us!

    All the best,
    Jamie Weinand

  3. i am glad to see this has taken me many years get hormones i have had a heart attack but not do to hrt i only take o.1 patch and 50 spiro but seems all i no are so far ahead of me would if possible get info on what i should be taking have 2 stents and i asked to be kept on blood thinner i don’t no if u can help thank you billie


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